Rhian Brewster struck twice inside the first five minutes as England U21s beat Italy 2-0 in a friendly in Pescara on Thursday evening.
Le Azzurre need a positive result to keep their qualification hopes alive, while France will emerge as Group D winners if they beat Belgium on Thursday.
Grace Geyoro scored a first-half hat-trick as France made a dream start to Euro 2022 by thrashing Italy 5-1 in Group D on Sunday.
European champions Italy endured a humiliating night in Monchengladbach, as they were thrashed 5-2 by Germany in the UEFA National League.
England could only manage a 0-0 draw against Italy at Molineux as Gareth Southgate's side remain bottom of Nations League Group A3.
England boss Gareth Southgate expressed concern at his team's reliance on Harry Kane after failing to score against Italy at Molineux.
Gareth Southgate says it is an "embarrassment" for England to be playing Italy behind closed doors in the Nations League on Saturday.
Copa America holders Argentina won the Finalissima with a convincing 3-0 win over European champions Italy at a packed Wembley.
Italy's Giorgio Chiellini says he will enjoy a "beautiful" end to his international career against Argentina at Wembley in Wednesday's Finalissima - but what is it?
The World Cup will be without Italy for the second edition in a row following what has been described back home as a "humiliating" defeat to North Macedonia.
Italy missed out on a second successive World Cup after losing to North Macedonia, while Portugal and Sweden took at step closer to Qatar 2022 with play-off wins.
Gareth Bale's brilliance carries Wales past Austria as Italy are stunned by North Macedonia on the road to Qatar 2022...
In-form France, ranked among the tournament favourites, take on Italy while Belgium face Iceland as Group D gets under way at Euro 2022.
Free highlights from a dramatic night of World Cup play-off semi-finals as North Macedonia stun Italy, and Portugal and Sweden take a step closer to Qatar 2022.
Wembley is on course to host the first edition of a new intercontinental event between the champions of Europe and South America.
Scotland and Wales could face off for a place at next year's World Cup should they defeat Ukraine and Austria in their respective play-off semi-finals.
Northern Ireland produced a performance of superb defensive discipline to hold European champions Italy to a 0-0 draw and send them into the World Cup play-offs.
Northern Ireland deny Italy an automatic spot at the 2022 World Cup with a heroic 0-0 draw in Belfast. Watch free match highlights.
Jorginho missed a penalty as Italy were held to a 1-1 draw by Switzerland, leaving both sides still with a chance of automatic qualification for Qatar from Group C.
Nicolo Barella's thunderous strike and a penalty converted by Domenico Berardi proved enough to earn hosts Italy a 2-1 victory over Belgium on Sunday.