Real Sociedad recovered from losing to Basque rivals Bilbao last weekend to see off Alaves in a 3-0 win on Saturday evening.
Las Palmas wasted the chance to move up to third in the La Liga table following a goalless draw with Espanyol.
Barcelona begin their Copa del Rey defence against Hercules, while Real face a trip to Leon to take on Cultural y Deportiva Leonesa.
Goals from Antoine Griezmann and Kevin Gameiro helped Atletico Madrid to a 2-0 win at Valencia on Sunday.
Valencia claimed their first win of the season, while there were away victories for Espanyol and Leganes in La Liga on Thursday evening.
The story of Mauricio Pochettino's first ever win as a coach - over Pep Guardiola's Barca.
Real Madrid overcame Espanyol 2-0 on Sunday to equal Barcelona's record of 16 consecutive La Liga wins.
Scroll back to see the live updates as Real Madrid beat Espanyol to win their 16th straight La Liga match.
Jon Driscoll and Terry Gibson return for an in-depth take on all the action and major talking points in La Liga.
Malaga battled back to secure a 2-2 draw away to Espanyol in La Liga on Friday evening, while Deportivo and Betis drew 0-0.
Tottenham have made a number of offers for Espanyol goalkeeper Pau Lopez, the Catalan club have told Sky Sports News HQ.
Sevilla twice recovered from going a goal down to secure a 6-4 home defeat of Espanyol in coach Jorge Sampaoli's first league fixture in charge.
Tottenham are interested in Espanyol's young goalkeeper Pau Lopez, according to Sky sources.
The 21st season of live Spanish football on Sky Sports gets underway this weekend with over 300 games available throughout the campaign.
Ahead of the new La Liga season, Guillem Balague picks out five up-and-coming players to keep an eye on in Spain.
Transfer sagas, managerial changes, new faces, old problems - Guillem Balague previews the new La Liga season.
Martin Demichelis will join La Liga side Espanyol on a free transfer following his departure from Manchester City.
Former Watford boss Quique Sanches Flores has been appointed the new head coach of Espanyol.
What was the best goal scored in La Liga this season? Watch 12 of the top strikes here and vote for your favourite...
Villarreal were crowned champions as Spain's top young talent competed at the La Liga Promises tournament.